GLP-1 Titration Calculator
Map your semaglutide or tirzepatide titration schedule with exact weekly doses. Supports compounded vials and brand pens (Ozempic, Wegovy, Mounjaro, Zepbound).
| Weeks | Dose | Syringe units | Phase |
|---|---|---|---|
| 1–4 | 0.25 mg | 5 units | Initiation |
| 5–8 | 0.5 mg | 10 units | Titration |
| 9–12 | 1 mg | 20 units | Titration |
| 13–16 | 1.7 mg | 34 units | Titration |
| 17+ | 2.4 mg | 48 units | Maintenance |
Concentration
50.0 mcg/unit
Vials for full titration
11
Disclaimer: This tool is for informational and educational purposes only. It is not medical advice. Consult a qualified healthcare provider before using any medication.
Titration schedules shown are based on FDA prescribing information and may not apply to all individuals or formulations.
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Frequently Asked Questions
What is the semaglutide titration schedule?
The FDA-approved semaglutide titration schedule starts at 0.25 mg weekly for 4 weeks, then increases to 0.5 mg (weeks 5–8), 1.0 mg (weeks 9–12), 1.7 mg (weeks 13–16), and a maintenance dose of 2.4 mg weekly. Titration helps minimize gastrointestinal side effects.
What is the tirzepatide titration schedule?
Tirzepatide starts at 2.5 mg weekly for 4 weeks, then increases in 2.5 mg increments every 4 weeks: 5 mg, 7.5 mg, 10 mg, 12.5 mg, up to a maximum maintenance dose of 15 mg weekly.
Why do GLP-1 peptides require titration?
Titration reduces gastrointestinal side effects like nausea and vomiting by allowing the body to gradually adapt to the medication. Starting at the full dose significantly increases the risk and severity of these side effects.
What if I miss a dose during titration?
If fewer than 5 days have passed since the missed dose, take it as soon as possible. If 5 or more days have passed, skip the missed dose and take the next dose on the regularly scheduled day. Do not double doses. Consult your healthcare provider for personalized guidance.