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Peptide Therapy

A researcher's guide to peptide therapy: how peptides work, the categories most often used (GH-releasing, metabolic, regenerative, cognitive, skin), safety and regulatory status, and where to start.

Reviewed by PeptideStack Editorial Team · Last reviewed

Quick answer

Peptide therapy is the use of short chains of amino acids — typically 2–50 residues long — to modulate specific physiological pathways. Some peptides are FDA-approved drugs (semaglutide, tirzepatide, tesamorelin, sermorelin); most on this site are research compounds without regulatory clearance for human use. Peptides act by binding specific receptors, which makes their effects narrow compared with small molecules but also limits oral bioavailability — most require injection.

What peptides do

Peptides are small proteins. They signal like hormones, bind receptors, and influence downstream gene expression. Because they target one or two pathways at a time, their effect profile tends to be narrower than small-molecule drugs — which is an advantage when you want precision and a disadvantage when you need oral dosing (most peptides are digested in the gut and require injection).

Categories of peptide therapy

The peptides most often discussed in research and clinical contexts fall into a handful of categories. Every category page below lists the peptides on this site that belong to it, with mechanisms, dose ranges used in published research, and regulatory status.

Regulatory status matters

A peptide can be FDA-approved for one use (e.g. semaglutide for type 2 diabetes), repurposed off-label for another (weight loss), available only through a compounding pharmacy, or sold as a research chemical with no human-use approval. The badge on every peptide profile reflects this. WADA-banned peptides are flagged for athletes; research-only peptides are flagged for everyone else.

Stacks and comparisons

Researchers frequently combine peptides to hit complementary pathways — a practice called stacking. Before committing to a stack, it helps to see how two peptides differ on a single outcome (e.g. GH release or fat loss). The comparison pages take this head-to-head view.

Where to start

Disclaimer

PeptideStack is informational only. It is not medical advice. Many peptides listed on this site are research compounds not approved for human use. Consult a qualified healthcare provider before using any compound.